The normal PSA levels vary with the age of a person. Generally, PSA levels of 4.0 ng/mL or less are considered normal (or ideal) in an adult male. In other words, if PSA levels are higher than 4.0 ng/mL; your doctor may advise either of the following: A repeat PSA test to rule out any infection or inflammatory process 3) Stress Reduction. Stress impacts the human system and serum prostate in a number of ways. With high stress, the PSA level spikes. So, find ways to relax and set your mind at ease before or after a prostate biopsy . Meditation, yoga, deep breathing, and regular physical activity can help. The authors found that the mean PSA level decreased with increasing BMI, such that the mean PSA level in men with a normal BMI (18.5–24.9 kg/m 2) was 1.01 ng/ml and the mean PSA level in Metrics. After definitive radiotherapy for prostate cancer, prostate-specific antigen (PSA) levels can transiently increase before ultimately dropping below the previous nadir sans intervention PSA testing can lead to overdiagnosis and missed cancers. It can be improved by adding a man's genetic chance of high or low PSA levels, study finds. a biopsy and "go down the pathway for It isn't cumulative. Every time you have an orgasm, your prostate has contractions that squeeze some of its PSA out into the serum. The PSA is cleared out within a couple of days. It doesn't accumulate. treedown in reply to Mascouche 3 years ago. I wondered about this in the context of my retro ejaculation. PSA velocity is given in ng/ml/year and can be thought of as a prediction: for example, a patient with a current PSA of 2 ng/ml and a PSA velocity of 0.5 ng/ml/year would be expected to have a PSA of 2.5 ng/ml in 12 months time. PSA doubling time is the number of months it would take for PSA to increase two-fold. Naturally, everyone is different, but even without radiation therapy the PSA can go very low. After 1-year of hormone therapy alone using Zoladex, Casodex (150 mg/day), and Avodart, my PSA fell from 19.6 to 0.02. After 15-months (last three without any medication except Avodart or Proscar) my PSA is 0.01. I expect the PSA will soon start to go As you get older, your prostate slowly enlarges and your PSA gradually increases. The larger your prostate, the higher the PSA. Prostate cancer (pictured) also becomes commoner with increasing age. By the age of 90 years, almost all men will have microscopic areas of tumour in the prostate. This does not mean that they have active prostate cancer. Cancer can also spread down the blood vessels, lymphatic channels, or nerves that go in and out of the prostate. Cancer cells can enter the blood vessels and lymphatic channels. Once prostate cancer has gotten inside these vessels, the cells can “seed” in almost any part of the body. Cancer can also make its way through the capsule that CsLtT.